NexGard Spectra Chewable tablets for fleas and ticks Small Dogs 3.5-7.5 kg, 3 tab
for the treatment and prevention of parasitic diseases in dogs
Composition and form of release
NexGard Spectra as active ingredients contains afoxolaner – 1.87% (in 1 tablet 9.4 mg, 18.8 mg, 37.5 mg, 75 mg and 150 mg) and milbemycin oxime – 0.38% (in 1 tablet 1.9 mg, 3.8 mg, 7.5 mg, 15 mg and 30 mg), as well as auxiliary substances: corn starch, soy protein flour, a food additive with the aroma and taste of stewed beef, povidone E1201, macrogol 400, macrogol 4000, macrogol 15 hydroxystearate, glycerol, medium chain triglyceride, citric acid monohydrate, butylhydroxytoluene.
In appearance, the drug is a round-shaped tablet from light pink to dark pink with reddish-brown blotches.
NexGard Spectra is available in five dosages: tablets weighing 0.5; 1.0; 2.0; 4.0 and 8.0 g, packaged in 3 tablets in blisters made of polyvinyl chloride and aluminum foil on a paper basis, which are individually packed in cardboard boxes along with instructions for use.
Pharmacological properties
NexGard Spectra refers to combined antiparasitic drugs.
The active ingredients of the drug – afoxolaner and milbemycin oxime provide its wide range of antiparasitic action against ectoparasites and nematodes parasitizing in dogs: fleas (Ctenocephalides felis, Ctenocephalides can is); ticks (Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Ixodes holocyclus, Haemaphysalis longicornis, Amblyomma americanum); gastrointestinal nematodes (Toxocara canis, Toxascaris leonina, Ancylostoma caninum, Ancylostoma braziliense, Trichuris vulpis); larvae of dirofilariae (Dirofilaria immitis).
Afoxolaner is an insectoacaricide of the isoxazoline group, the mechanism of its action is to block GABA-dependent receptors in arthropods, hyperexcitation of neurons, impaired transmission of nerve impulses, which leads to paralysis and death of ectoparasites. After oral administration, afoxolaner is easily absorbed in the gastrointestinal tract and reaches the systemic circulation, the maximum plasma concentration is observed 2-4 hours after administration, the bioavailability is 88%. Afoxolaner is slowly metabolized with the formation of hydroxylated compounds, excreted from the body mainly in the bile and slightly in the urine. The half-life of afoxolaner is 14 days.
Milbemycin oxime is a macrocyclic lactone, active against larvae and adults of nematodes parasitizing in the gastrointestinal tract of dogs, as well as larvae of Dirofilaria immitis. The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes for chlorine ions (SG), which leads to overpolarization of the membranes of the cells of the nervous and muscle tissue, paralysis and death of the parasite. The maximum concentration of milbemycin oxime in the blood plasma of dogs is reached within 1-2 hours, the bioavailability is 81%. The compound is excreted from the body mainly unchanged, the half-life is about 1.5 days.
The insecticidal effect of the drug begins 30 minutes after its oral administration, the death of fleas and ixodid ticks on the animal occurs, respectively, for 6 hours and 24 hours. A single use of the drug prevents re-infestation within 1 month; the death of fleas occurs before oviposition, which prevents contamination of the premises with eggs and insect larvae.
NexGard Spectra, according to the degree of impact on the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76), in recommended doses it does not have teratogenic, embryotoxic, mutagenic properties, does not have a local irritating effect. The drug is toxic to bees, as well as fish and other aquatic organisms.
Indications
NexGard Spectra is prescribed to dogs for the treatment and prevention of gastrointestinal nematodes, acarosis caused by ixodid ticks, aphanipterosis, in the complex therapy of allergic dermatitis caused by fleas, as well as for the prevention of dirofilariasis caused by larvae of Dirofilaria immitis.
Doses and method of administration
NexGard Spectra is administered to dogs individually orally once in a minimum dose of 2.5 mg of afoxolaner and 0.5 mg of milbemycin oxime per 1 kg of animal weight in accordance with the table:
| Dog weight (kg) | Tablet weight (g) | Dose of active ingredients (mg / tablet) | |
| afoxolaner | milbemycin oxime | ||
| from 2 to 3.5 | 0.5 | 9.4 | 1.9 |
| from 3.5 to 7.5 | 1.0 | 18.8 | 3.8 |
| from 7.5 to 15 | 2.0 | 37.5 | 7.5 |
| from 15 to 30 | 4.0 | 75.0 | 15.0 |
| from 30 to 60 | 8.0 | 150.0 | 30.0 |
When using the drug in dogs weighing more than 60 kg, a combination of tablets should be used, at the rate of 2.5 mg of afoxolaner and 0.5 mg of milbemycin oxime per 1 kg of body weight. It is not allowed to break the tablets when selecting the dose of the drug.
NexGard Spectra has an attractive aroma and taste and, as a rule, is readily eaten by dogs, otherwise, the drug is fed in a mixture with food. Make sure the dog has completely swallowed the required dose of the drug.
In order to prevent dirofilariasis in regions unsuccessful in terms of the disease, NexGard Spectra is used in the spring-summer-autumn period every month, starting one month before the start of the flight of the pathogen vectors – mosquitoes and mosquitoes, and ends no earlier than a month after the end of their flight.
Violations of the drug use regimen should be avoided, as this can lead to a decrease in its effectiveness. In case of missing the next treatment, the use of the drug should be resumed in the same dose and according to the same scheme.
The peculiarities of the action of the drug during its first use and withdrawal were not revealed.
Pregnant and lactating bitches NexGard Spectra are used for health reasons on the recommendation of a veterinarian.
Side effects
When using the drug in accordance with this instruction, side effects and complications in animals, as a rule, are not observed. Some animals may have a short-term decrease in appetite, spontaneously disappearing skin changes (erythema, peeling, itching); rarely – vomiting, diarrhea and drowsiness. If the dog vomits within the first two hours after taking NexGard Spectra, it is recommended to give the drug again in the same dose.
In case of an overdose of the drug, some dogs may experience depression, salivation, trembling, and a shaky gait. These symptoms disappear spontaneously within 24 hours and do not require the use of drugs.
Contraindications
Contraindication to use is the increased individual sensitivity of the animal to the components of the drug, pronounced violations of the liver and kidneys. The drug should not be used by patients with infectious diseases and weakened animals, dogs under 8 weeks of age and / or weighing less than 2 kg, as well as animals of other species. For puppies of dog breeds sensitive to macrocyclic lactones, including collie, bobtail and sheltie, the drug is used under the supervision of a veterinarian.
special instructions
There is no information about the incompatibility of NexGard Spectra with other drugs and feed additives.
NexGard Spectrum is not intended for use in productive animals.
Personal prevention measures
When working with NexGard Spectra, you should follow the general rules of personal hygiene and safety measures provided for when working with veterinary medicinal products.
Do not smoke, drink or eat while working. After handling the medicinal product, wash your hands thoroughly with soap and water. It is forbidden to use empty packaging from under the medicinal product for household purposes; it is placed in a plastic bag and disposed of with household waste.
People with hypersensitivity to the components of the drug should avoid direct contact with NexGard Spectra. In case of allergic reactions or in case of accidental ingestion of the drug into the human body, you should immediately contact a medical institution, having a label or instructions for use of the drug with you.
Storage conditions
Store the medicinal product in the manufacturer’s closed packaging, in a dry place, protected from direct sunlight, out of reach of children, separately from food and feed, at a temperature of 0 ° C to 30 ° C.
The shelf life of the medicinal product, subject to storage conditions in the manufacturer’s sealed packaging, is 24 months from the date of production.
It is forbidden to use the medicinal product after the expiration date. Unused medicinal product is disposed of in accordance with legal requirements.
NexGard Spectra is available without a veterinarian’s prescription.
