Funin forte spray (terbinafine hydrochloride, thiabendazole, metronidazole, lidocaine hydrochloride, dexamethasone sodium phosphate)
For the treatment of fungal skin diseases, eczema of fungal etiology and seborrheic dermatitis in dogs and cats.
General Information
In appearance, the drug is a solution from light yellow to dark yellow. For external use.
Trade name of the drug: Fungin forte.
International non-proprietary name: terbinafine, thiabendazole, metronidazole, lidocaine, dexamethasone.
Fungin forte in 1 ml as active substances contains: terbinafine hydrochloride – 10 mg, thiabendazole – 10 mg, metronidazole – 10 mg, lidocaine hydrochloride – 50 mg, dexamethasone sodium phosphate – 1 mg.
Excipients: gasoline alcohol – 300 mg, dimethyl sulfoxide – 100 mg, orange terpene – 5 mg and polyethylene glycol-400 – up to 1 ml.
Pharmacological properties
Fungin forte refers to combined antifungal drugs.
Terbinafine is an antifungal agent of the allylamine group, active against pathogens of dermatomycoses in animals. The mechanism of action is to suppress squalene epoxidase in the cell membrane of the fungus. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes cell death of the pathogen. Depending on the concentration, terbinafine has a fungicidal or fungistatic effect. Due to the high lipophilicity of terbinafine molecules accumulate in the stratum corneum of the dermis, hair follicles, sebaceous glands; when applied topically to the systemic circulation, the drug penetrates insignificantly.
Thiabendazole is a fungicide from the azole class. Active against pathogens of trichophytia and microspores of animals of the genera Trichophyton, Microsporum, Epidermophyton, Achorion. Like other azoles, it blocks the activity of enzymes involved in the 14-demstylation of lanosterol, which leads to disruption of ergosterol synthesis. Changing the structure of the cytoplasmic membrane of fungal cells leads to a violation of its permeability, the release of biologically active substances from the cell and the destruction of the cell wall. In addition, thiabendazole disrupts the division of the nucleus, inhibits the reproductive capacity of fungi.
Metronidazole is a drug from the group of nitroimidazoles. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the bacterial cell, inhibiting the synthesis of nucleic acids, which leads to the death of the microorganism.
Dexamethasone is a synthetic glucocorticosteroid, a methylated derivative of fluoroprednisolone. Has anti-inflammatory, anti-allergic, desensitizing, immunosuppressive, antishock and antitoxic effects, increases the sensitivity of beta-blockers to endogenous catecholamines. The mechanism of action of dexamethasone is to suppress the activity of various enzymes that destroy tissues – proteases and nucleases, matrix metalloproteinases, hyaluronidase, phospholipase, inhibiting the synthesis of prostaglandins, kinins, leukotrienes and other mediators of inflammatory arachidinate.
Lidocaine – has a local anesthetic effect, blocks potential-dependent heating channels, which prevents the generation of impulses at the ends of sensitive nerves and the conduction of impulses through nerve fibers.
Fungin forte by the degree of impact on the body is a low-risk substance (hazard class 4 according to GOST 12.1.007-76), in the recommended doses does not have a local irritant, resorptive-toxic and sensitizing effect. Causes slight eye irritation.
The order of application
Fungin forte is prescribed to dogs and cats for the treatment of fungal skin diseases, eczema of fungal etiology and seborrheic dermatitis.
Fungin forte is applied in a thin layer with a cotton gauze swab, as well as spraying or applying directly to the skin from a vial – dropper, lightly rubbing into the affected areas from the periphery to the center with capture up to 1 cm of healthy border skin. Treatments are performed once or twice a day until clinical recovery, but not more than 15 days, which is confirmed by microscopic examination of skin scrapings.
To prevent licking of the drug, animals wear a muzzle, collar or close the jaws with a loop of tape, which is removed 15-20 minutes after treatment.
In severe disease, animals are additionally prescribed drugs for specific and symptomatic therapy in accordance with the instructions for use.
Contraindication
Contraindication to use is the hypersensitivity of the animal to the components of the drug. Weakened animals that feed and pregnant females, as well as puppies and kittens under 4 weeks of age are not subject to treatment.
Overdose
No symptoms of overdose have been identified.
Features of action
Peculiarities of action at the first use of drug and at its cancellation are not revealed.
Features of application
In case of skipping the next treatment, the drug is resumed in the same dose, according to the same scheme.
Fungin forte should not be used concomitantly with other topical preparations containing corticosteroid hormones.
Fungin forte is not intended for use in productive animals.
Side effect
Side effects and complications when using the drug Fungin forte according to these instructions are not observed. At the increased individual sensitivity of animals to components of drug and emergence of signs of skin irritation, processing is stopped, Fungin forte remove a tampon and wash off with water, appoint to an animal antihistamines and means of symptomatic therapy.
Personal prevention measures
When working with the drug Fungin forte should follow the general rules of personal hygiene and safety provided when working with drugs, use rubber gloves when handling animals. Wash hands with warm soapy water after use.
In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they should be rinsed immediately with plenty of water.
People with hypersensitivity to the components of the drug should avoid direct contact with the drug Fungin forte. In case of allergic reactions or accidental ingestion of the drug, you should immediately contact a medical institution (have instructions for use of the drug or label).
Release form
Fungin forte is produced in polymer bottles with mechanical spray heads of 30 ml. Each consumer package is supplied with instructions for use.
Storage conditions
Store the drug in a closed package of the manufacturer, separately from food and feed, in a dry place, protected from direct sunlight at a temperature of 0 ° C to 25 ° C.
Fungin forte should be stored out of the reach of children.
Expiration date
Shelf life of Fungin forte in compliance with the conditions of storage in a closed package of the manufacturer – 2 years from the date of manufacture, after opening the bottle – 30 days.
It is forbidden to use the drug Fungin forte after the expiration date.
Any unused product should be disposed of in accordance with local requirements.
Empty vials under the drug must not be used for household purposes, they must be disposed of with household waste.
