Ivermectin

The anti-inflammatory properties of topical ivermectin have been observed in animal models of inflammatory skin processes. Ivermectin also causes death of parasites, mainly through selective binding and high affinity for glutamate-regulated chlorine channels found in nerve and muscle cells of invertebrates. The mechanism of action of ivermectin in the treatment of inflammatory skin lesions in rosacea is not known, but may be associated with both the anti-inflammatory effects of ivermectin and the ability of ivermectin to kill Demodex mites, which, in turn, are a factor causing skin inflammation.